Evidence for the Asiatic origin of endogenous AKR-type murine leukemia proviruses
نویسندگان
چکیده
منابع مشابه
Murine Leukemia Virus Antigens in Akr
It is now well established that viruses of the murine leukemia virus (MuLV)' group are present ifi all m i ~ (1, 2) and that viral genetic sequences are present as chromosomal DNA (3-5). The expression of this genetic material, as virus particles or viral antigens, differs markedly between strains of mice, both with regard to the age at which the expression occurs (6-8) and the spectrum of biol...
متن کاملAmplified env and gag products on AKR cells. Origin from different murine leukemia virus genomes
Thymocytes of AKR mice express two species of gp70, the envelope glycoprotein of murine leukemia virus (MuLV), encoded by the env gene. One is denoted Ec+ gp70 in reference to the type-antigen Ec and association with ecotropic virus. The other, Ec- gp70, resembles gp70 found also on thymocytes of mouse strains that are not overt producers of MuLV, and has no evident relation to ecotropic virus....
متن کاملIdentification of DNA fragments carrying ecotropic proviruses of AKR mice.
The proviruses of the N-tropic, ecotropic virus (AKV) of AKR mice (Akv-1, Akv-2) have been studied by the Southern gel--filter transfer technique. These proviruses can be detected by cleavage of cell DNA by BamHI endonuclease, which yields characteristic subgenomic DNA fragments upon cleavage of this type of provirus. Proviruses integrated into different sites in the mouse genome can be resolve...
متن کاملMurine Leukemia Virus Group-specific Antigen Expression in AKR Mice1
The distribution of the group-specific murine leukemia virus antigen was studied by immunofluorescence and immunofluorescence absorption in embryo, neonatal, and postnatal normal AKR mice of various ages and in leukemic mice of this strain. MuLV-fs antigens were first detected during the first postnatal week in the liver, spleen, bone marrow, and serum, and during the second postnatal week in t...
متن کاملMurine leukemia virus group-specific antigen expression in AKR mice.
The distribution of the group-specific murine leukemia virus antigen was studied by immunofluorescence and immunofluorescence absorption in embryo, neonatal, and postnatal normal AKR mice of various ages and in leukemic mice of this strain. MuLV-fs antigens were first detected during the first postnatal week in the liver, spleen, bone marrow, and serum, and during the second postnatal week in t...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1980
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.35.3.824-835.1980